Microneedling has become one of today’s most sought-after treatments for skin rejuvenation — a minimally invasive procedure that naturally renews the skin from within. By creating precise, microscopic channels on the skin’s surface, microneedling triggers your body’s intrinsic healing response, stimulating collagen and elastin production. The result is smoother, firmer, and more luminous skin with minimal downtime.At Ortali Wellness, our providers perform microneedling both on its own and paired with Platelet-Rich Plasma (PRP) or topical exosomes.
PRP is derived from your own blood and is rich in platelets and growth factors that stimulate collagen production, improve skin texture, and promote natural healing. It helps reduce fine lines, minimize acne scars, and restore skin vitality.
Exosomes are a concentrated component of PRP, containing regenerative proteins and signaling molecules that enhance cellular communication and accelerate tissue repair. When applied topically with microneedling, exosomes help your skin heal faster, rejuvenate more deeply, and achieve a smoother, youthful glow.
When combined, microneedling + PRP + exosomes works synergistically to accelerate cellular renewal, reduce imperfections, and restore a healthy, radiant complexion — all while maintaining natural-looking, subtle results.
This treatment effectively improves:
Microneedling uses a specialized device equipped with ultra-fine, sterile needles to create micro-injuries across the treatment area. These controlled punctures initiate a cascade of natural repair mechanisms — stimulating fibroblasts to generate new collagen and elastin, the essential proteins responsible for skin firmness and elasticity.
As the skin heals, it becomes stronger, smoother, and more evenly toned. This process also enhances the penetration of medical-grade serums and nutrients applied afterward, further amplifying results.
Because it harnesses your body’s own biology, microneedling offers a natural, safe, and highly effective approach to skin rejuvenation.
For an enhanced result, Platelet-Rich Plasma (PRP) can be added to the procedure.
PRP is created from a small sample of your own blood, which is processed in a centrifuge to isolate the plasma layer rich in growth factors — powerful proteins that accelerate tissue regeneration and healing.
When applied immediately after microneedling, PRP penetrates deeply through the microchannels, amplifying collagen remodeling and improving recovery. This combination delivers more visible improvement in texture, tone, and radiance compared to microneedling alone.
Benefits of adding PRP include:
For patients seeking cutting-edge regenerative results, topical exosomes can be added to the microneedling procedure. Exosomes are concentrated signaling molecules and regenerative proteins derived from your own cells, designed to enhance cellular communication and accelerate tissue repair.
When applied immediately after microneedling, exosomes penetrate the microchannels created by the treatment, amplifying collagen production, promoting skin renewal, and supporting faster recovery. This combination delivers more noticeable improvements in texture, tone, and radiance compared to microneedling alone.
This treatment is ideal for patients seeking subtle yet powerful rejuvenation, maintaining natural beauty while restoring a youthful, healthy complexion.
Your comfort and safety are our top priorities.
Downtime is minimal, and most patients return to normal activities the following day.
For best results:
Your skin may appear more luminous within a few days, with collagen remodeling continuing for several weeks. Optimal results become visible after 4–6 weeks, as new collagen strengthens the dermal structure.
Results typically last 3–5 months. For ongoing rejuvenation, we recommend monthly treatments until goal is reached, and then quarterly sessions as part of your long-term skincare plan.
Microneedling ± PRP ± exosomes are safe and effective for the face and many areas of the body, including:
Microneedling ± PRP ± exosomes are suitable for both men and women seeking healthier, smoother, and more radiant skin. It’s safe for nearly all skin types and tones.
You may be an ideal candidate if you:
A consultation at Ortali Wellness ensures your treatment is customized safely and effectively for your skin’s unique needs.
To prepare for your microneedling treatment:
While both treatments rejuvenate the skin, microneedling and microneedling with PRP differ in intensity and results.
It takes about 45 minutes and uses a topical numbing cream to ensure comfort. It does not require a blood draw and effectively stimulates collagen production, improving skin firmness and reducing fine lines with minimal downtime.
Microneedling with PRP , on the other hand, adds an additional step—drawing a small sample of your blood to extract platelet-rich plasma. The procedure takes about an hour and enhances results by infusing the skin with concentrated growth factors. This addition accelerates healing, amplifies collagen production, and enhances the treatment’s overall outcome. Patients often notice quicker, more dramatic improvements in tone, texture, and radiance compared to microneedling alone.
Microneedling with exosomes typically takes 45–60 minutes, similar to a PRP procedure. After microneedling, exosomes—concentrated regenerative proteins and signaling molecules—are applied topically to the skin. This enhances cellular repair, stimulates collagen remodeling, and promotes deep skin rejuvenation. Patients often notice faster healing, improved texture and tone, and a radiant, youthful glow, either as a standalone treatment or in combination with PRP for amplified results.
In summary, while both options are excellent for rejuvenation, microneedling with PRP and exosomes delivers a more powerful, regenerative boost with faster recovery and more pronounced long-term benefits.
Microneedling ± PRP ± exosomes is a safe procedure when performed by trained medical professionals. Mild, temporary effects may include:
Rare risks, such as infection or prolonged irritation, are minimized through sterile technique and proper aftercare.
Microneedling sessions typically range between $400 – $800, depending on treatment area, intensity, and whether PRP or exosomes are included. Because these are elective aesthetic procedures, insurance does not cover treatment.
To maintain results, most patients schedule maintenance sessions every few months, combined with daily SPF and medical-grade skincare.
At Ortali Wellness, our team combines medical expertise with advanced technology to deliver refined, natural results. Every procedure is thoughtfully customized to your goals, ensuring beautiful outcomes that feel authentic and effortless.
Ready to restore smoother, more luminous skin?
Schedule your consultation today and discover the regenerative power of Microneedling ± PRP ± Exosomes at Ortali Wellness.
At Ortali Wellness, we combine medical expertise with artistic precision to provide subtle, transformative enhancements that highlight your best features. Every treatment is tailored to your individual facial anatomy and aesthetic goals. We prioritize natural results, patient comfort, and education, guiding you through every step of your dermal filler journey. Our approach ensures that you leave our clinic feeling confident, radiant, and beautifully balanced.
It is a skin rejuvenation treatment that combines microneedling with Platelet-Rich Plasma (PRP) from your own blood. PRP boosts healing and collagen production. Exosomes may be added to enhance cell regeneration and improve overall results.
It helps improve acne scars, fine lines, enlarged pores, uneven texture, pigmentation, and overall skin quality. It can also support hair restoration when used on the scalp.
Mild redness and sensitivity are common for 1–3 days. Most patients resume normal activities quickly, with visible improvements developing gradually over several weeks.
Most patients see noticeable improvement after one session, but a series of 3–4 treatments spaced about 4–6 weeks apart delivers the best results. The exact number depends on your skin goals, concerns (such as acne scarring, texture, or pigmentation), and how your skin responds. Maintenance treatments may be recommended 1–2 times per year.
Neither is “better” universally—they serve different purposes. PRP (Platelet-Rich Plasma) uses your own growth factors to stimulate collagen and healing, making it a great option for overall skin rejuvenation. Exosomes are more advanced signaling molecules that can enhance cellular communication and recovery, often producing faster or more dramatic results. The best choice depends on your skin needs and treatment goals.
Yes. Microneedling pairs well with injectables when properly timed. It’s commonly combined with neuromodulators or fillers as part of a comprehensive skin plan, but treatments are typically scheduled separately to allow for optimal healing and results. Your provider will create a customized timeline to ensure safety and effectiveness.
Downtime is minimal. Most patients experience redness and mild sensitivity for 24–72 hours, similar to a sunburn. Light flaking or dryness may occur as the skin renews itself. Makeup is usually safe after 24 hours, and normal activities can resume quickly with proper post-care.
Discover expert cosmetic and medical treatments in Los Angeles with Ortali Wellness, including fillers, PRP, weight loss, and IV therapy for natural, lasting results and vitality.
Expert neuromodulator treatments for natural movement and long-lasting results.
Precision chemical peel treatments that renew, smooth, and brighten your skin for natural-looking, long-lasting results.
Personalized medical weight loss programs for safe, effective, and sustainable results.
Precision dermal fillers to restore volume, refine contours, and enhance natural beauty.
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Customized IV therapy to boost hydration, energy, immunity, and overall wellness.
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